Is the process of stabilization of carotid plaque more dynamic than expected? a high-resolution 3D-CMR statin-naive human study
نویسندگان
چکیده
Purpose Methods Via CMR (1.5T GE), 707-two mm contiguous in vivo slices of advanced carotid disease (>50%; mean 64±21 ) representing 42 complete bilateral human plaques (age 68±15yrs) were analyzed for 2D/3D extent of vascular wall: lipid pool, fibrous cap, outer wall area (OWA), vessel wall area (VWA), lumen area (LA) and lipid pool (LP). All were related to fasting lipids relative to %stenosis via QPlaque (Medis). Plaque morphology was determined by CMR (T1/T2/PD) at baseline and one year following lipid lowering agent (simvastatin or simva/ ezetimibe). Plaque progression was defined as LP pre/LP post < 1 while plaque regression was defined as LP pre/ LP post >1.
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